| Sikeston to Southern Pines (North Carolina) | 580.56 mi (934.32 km) |
| Sikeston to Southfield (Michigan) | 511.97 mi (823.93 km) |
| Sikeston to Southgate (Michigan) | 500.40 mi (805.31 km) |
| Sikeston to Southlake (Texas) | 507.02 mi (815.97 km) |
| Sikeston to Spanaway (Washington) | 1,811.09 mi (2,914.67 km) |
| Sikeston to Spanish Fork (Utah) | 1,209.86 mi (1,947.08 km) |
| Sikeston to Spanish Lake (Missouri) | 135.77 mi (218.49 km) |
| Sikeston to Spanish Springs (Nevada) | 1,635.25 mi (2,631.68 km) |
| Sikeston to Sparks (Nevada) | 1,638.04 mi (2,636.16 km) |
| Sikeston to Spartanburg (South Carolina) | 449.12 mi (722.78 km) |
| Sikeston to Spearfish (South Dakota) | 909.91 mi (1,464.36 km) |
| Sikeston to Speedway (Indiana) | 270.39 mi (435.15 km) |
| Sikeston to Spencer (Iowa) | 523.07 mi (841.80 km) |
| Sikeston to Spokane (Washington) | 1,594.47 mi (2,566.04 km) |
| Sikeston to Spokane Valley (Washington) | 1,585.58 mi (2,551.74 km) |
