| Sikeston to Spout Springs (North Carolina) | 599.50 mi (964.80 km) |
| Sikeston to Spring (Texas) | 577.53 mi (929.44 km) |
| Sikeston to Spring Creek (Nevada) | 1,420.00 mi (2,285.27 km) |
| Sikeston to Spring Hill (Florida) | 710.64 mi (1,143.67 km) |
| Sikeston to Spring Hill (Tennessee) | 168.57 mi (271.29 km) |
| Sikeston to Spring Lake (North Carolina) | 603.00 mi (970.43 km) |
| Sikeston to Spring Valley (California) | 1,574.42 mi (2,533.79 km) |
| Sikeston to Spring Valley (Nevada) | 1,422.99 mi (2,290.09 km) |
| Sikeston to Spring Valley (New York) | 882.59 mi (1,420.39 km) |
| Sikeston to Springboro (Ohio) | 344.30 mi (554.10 km) |
| Sikeston to Springdale (Arkansas) | 258.16 mi (415.47 km) |
| Sikeston to Springdale (New Jersey) | 817.08 mi (1,314.96 km) |
| Sikeston to Springdale (Ohio) | 323.80 mi (521.10 km) |
| Sikeston to Springfield (Illinois) | 199.40 mi (320.91 km) |
| Sikeston to Springfield (Massachusetts) | 975.95 mi (1,570.63 km) |
