| Sikeston to St. George (Utah) | 1,320.51 mi (2,125.15 km) |
| Sikeston to St. Helens (Oregon) | 1,815.40 mi (2,921.61 km) |
| Sikeston to St. James (New York) | 924.36 mi (1,487.61 km) |
| Sikeston to St. John (Indiana) | 334.68 mi (538.61 km) |
| Sikeston to St. Joseph (Missouri) | 346.19 mi (557.13 km) |
| Sikeston to St. Louis (Missouri) | 126.16 mi (203.04 km) |
| Sikeston to St. Louis Park (Minnesota) | 590.82 mi (950.83 km) |
| Sikeston to St. Marys (Georgia) | 624.84 mi (1,005.58 km) |
| Sikeston to St. Marys (Pennsylvania) | 670.34 mi (1,078.81 km) |
| Sikeston to St. Matthews (Kentucky) | 235.91 mi (379.66 km) |
| Sikeston to St. Michael (Minnesota) | 612.87 mi (986.33 km) |
| Sikeston to St. Paul (Minnesota) | 586.37 mi (943.67 km) |
| Sikeston to St. Peter (Minnesota) | 563.06 mi (906.15 km) |
| Sikeston to St. Peters (Missouri) | 142.37 mi (229.12 km) |
| Sikeston to St. Petersburg (Florida) | 746.43 mi (1,201.26 km) |
