| Sikeston to St. Simons (Georgia) | 612.82 mi (986.24 km) |
| Sikeston to Stafford (Texas) | 608.60 mi (979.44 km) |
| Sikeston to Stallings (North Carolina) | 513.72 mi (826.76 km) |
| Sikeston to Stamford (Connecticut) | 907.17 mi (1,459.94 km) |
| Sikeston to Stanford (California) | 1,785.47 mi (2,873.43 km) |
| Sikeston to Stanton (California) | 1,609.07 mi (2,589.54 km) |
| Sikeston to Star (Idaho) | 1,486.27 mi (2,391.92 km) |
| Sikeston to Starkville (Mississippi) | 240.46 mi (386.98 km) |
| Sikeston to State College (Pennsylvania) | 685.86 mi (1,103.79 km) |
| Sikeston to Staten Island (New York) | 869.06 mi (1,398.61 km) |
| Sikeston to Statesboro (Georgia) | 539.67 mi (868.51 km) |
| Sikeston to Statesville (North Carolina) | 490.90 mi (790.02 km) |
| Sikeston to Staunton (Virginia) | 583.19 mi (938.56 km) |
| Sikeston to Steamboat Springs (Colorado) | 960.48 mi (1,545.75 km) |
| Sikeston to Steiner Ranch (Texas) | 656.29 mi (1,056.20 km) |
