| Sikeston to Stephenville (Texas) | 587.38 mi (945.30 km) |
| Sikeston to Sterling (Colorado) | 776.16 mi (1,249.11 km) |
| Sikeston to Sterling (Illinois) | 339.59 mi (546.51 km) |
| Sikeston to Sterling (Virginia) | 679.20 mi (1,093.06 km) |
| Sikeston to Sterling Heights (Michigan) | 525.25 mi (845.31 km) |
| Sikeston to Steubenville (Ohio) | 538.58 mi (866.77 km) |
| Sikeston to Stevens Point (Wisconsin) | 527.79 mi (849.39 km) |
| Sikeston to Stevenson Ranch (California) | 1,631.30 mi (2,625.33 km) |
| Sikeston to Stillwater (Minnesota) | 589.30 mi (948.38 km) |
| Sikeston to Stillwater (Oklahoma) | 418.90 mi (674.15 km) |
| Sikeston to Stockbridge (Georgia) | 381.20 mi (613.48 km) |
| Sikeston to Stockton (California) | 1,733.73 mi (2,790.17 km) |
| Sikeston to Stone Ridge (Virginia) | 670.41 mi (1,078.93 km) |
| Sikeston to Stonecrest (Georgia) | 378.60 mi (609.29 km) |
| Sikeston to Stony Brook (New York) | 926.03 mi (1,490.31 km) |
