| Sikeston to Storm Lake (Iowa) | 496.71 mi (799.38 km) |
| Sikeston to Storrs (Connecticut) | 984.63 mi (1,584.61 km) |
| Sikeston to Stoughton (Wisconsin) | 417.65 mi (672.15 km) |
| Sikeston to Stow (Ohio) | 528.21 mi (850.07 km) |
| Sikeston to Streamwood (Illinois) | 362.70 mi (583.70 km) |
| Sikeston to Streator (Illinois) | 295.70 mi (475.89 km) |
| Sikeston to Streetsboro (Ohio) | 534.43 mi (860.08 km) |
| Sikeston to Strongsville (Ohio) | 515.93 mi (830.32 km) |
| Sikeston to Stuart (Florida) | 863.66 mi (1,389.93 km) |
| Sikeston to Stuarts Draft (Virginia) | 583.75 mi (939.45 km) |
| Sikeston to Sturgis (Michigan) | 405.95 mi (653.31 km) |
| Sikeston to Suamico (Wisconsin) | 541.32 mi (871.16 km) |
| Sikeston to Sudley (Virginia) | 672.24 mi (1,081.86 km) |
| Sikeston to Suffern (New York) | 877.84 mi (1,412.75 km) |
| Sikeston to Suffolk (Virginia) | 716.01 mi (1,152.30 km) |
