| Sikeston to Superior (Colorado) | 867.69 mi (1,396.42 km) |
| Sikeston to Superior (Wisconsin) | 689.69 mi (1,109.95 km) |
| Sikeston to Surprise (Arizona) | 1,305.15 mi (2,100.44 km) |
| Sikeston to Susanville (California) | 1,683.00 mi (2,708.53 km) |
| Sikeston to Sussex (Wisconsin) | 437.76 mi (704.51 km) |
| Sikeston to Suwanee (Georgia) | 367.07 mi (590.74 km) |
| Sikeston to Swansea (Illinois) | 117.10 mi (188.45 km) |
| Sikeston to Sweetwater (Florida) | 939.33 mi (1,511.71 km) |
| Sikeston to Sweetwater (Texas) | 685.83 mi (1,103.73 km) |
| Sikeston to Sycamore (Illinois) | 356.37 mi (573.53 km) |
| Sikeston to Sylacauga (Alabama) | 317.83 mi (511.50 km) |
| Sikeston to Sylvania (Ohio) | 457.94 mi (736.98 km) |
| Sikeston to Syosset (New York) | 905.60 mi (1,457.43 km) |
| Sikeston to Syracuse (New York) | 827.81 mi (1,332.24 km) |
| Sikeston to Syracuse (Utah) | 1,238.04 mi (1,992.43 km) |
