| Sikeston to The Villages (Florida) | 705.49 mi (1,135.38 km) |
| Sikeston to The Woodlands (Texas) | 575.49 mi (926.16 km) |
| Sikeston to Thibodaux (Louisiana) | 494.98 mi (796.60 km) |
| Sikeston to Thomasville (Georgia) | 527.10 mi (848.28 km) |
| Sikeston to Thomasville (North Carolina) | 533.13 mi (857.98 km) |
| Sikeston to Thonotosassa (Florida) | 743.67 mi (1,196.81 km) |
| Sikeston to Thornton (Colorado) | 856.29 mi (1,378.06 km) |
| Sikeston to Thousand Oaks (California) | 1,650.64 mi (2,656.45 km) |
| Sikeston to Three Lakes (Florida) | 946.48 mi (1,523.21 km) |
| Sikeston to Tiffin (Ohio) | 451.24 mi (726.19 km) |
| Sikeston to Tifton (Georgia) | 510.33 mi (821.30 km) |
| Sikeston to Tigard (Oregon) | 1,809.89 mi (2,912.74 km) |
| Sikeston to Tillmans Corner (Alabama) | 442.62 mi (712.33 km) |
| Sikeston to Timberlake (Virginia) | 570.28 mi (917.77 km) |
| Sikeston to Timberlane (Louisiana) | 484.83 mi (780.26 km) |
