| Sikeston to University Place (Washington) | 1,818.29 mi (2,926.26 km) |
| Sikeston to Upland (California) | 1,584.84 mi (2,550.55 km) |
| Sikeston to Upper Arlington (Ohio) | 413.91 mi (666.13 km) |
| Sikeston to Upper Grand Lagoon (Florida) | 514.11 mi (827.38 km) |
| Sikeston to Upper Montclair (New Jersey) | 870.41 mi (1,400.78 km) |
| Sikeston to Urbana (Illinois) | 235.18 mi (378.48 km) |
| Sikeston to Urbana (Maryland) | 686.19 mi (1,104.31 km) |
| Sikeston to Urbana (Ohio) | 386.00 mi (621.20 km) |
| Sikeston to Urbandale (Iowa) | 397.62 mi (639.91 km) |
| Sikeston to Utica (New York) | 871.26 mi (1,402.16 km) |
| Sikeston to Uvalde (Texas) | 792.27 mi (1,275.04 km) |
| Sikeston to Vacaville (California) | 1,765.84 mi (2,841.85 km) |
| Sikeston to Vadnais Heights (Minnesota) | 593.03 mi (954.39 km) |
| Sikeston to Vail (Arizona) | 1,245.60 mi (2,004.59 km) |
| Sikeston to Valdosta (Georgia) | 551.87 mi (888.14 km) |
