| Sikeston to Yonkers (New York) | 888.99 mi (1,430.69 km) |
| Sikeston to Yorba Linda (California) | 1,595.14 mi (2,567.13 km) |
| Sikeston to York (Pennsylvania) | 726.93 mi (1,169.88 km) |
| Sikeston to Yorktown (Indiana) | 316.83 mi (509.89 km) |
| Sikeston to Yorkville (Illinois) | 335.19 mi (539.44 km) |
| Sikeston to Youngstown (Ohio) | 561.10 mi (903.01 km) |
| Sikeston to Youngsville (Louisiana) | 489.14 mi (787.19 km) |
| Sikeston to Ypsilanti (Michigan) | 487.68 mi (784.84 km) |
| Sikeston to Yuba City (California) | 1,742.63 mi (2,804.49 km) |
| Sikeston to Yucaipa (California) | 1,552.24 mi (2,498.08 km) |
| Sikeston to Yucca Valley (California) | 1,516.29 mi (2,440.24 km) |
| Sikeston to Yukon (Oklahoma) | 465.35 mi (748.91 km) |
| Sikeston to Yulee (Florida) | 630.98 mi (1,015.46 km) |
| Sikeston to Yuma (Arizona) | 1,443.40 mi (2,322.93 km) |
| Sikeston to Zachary (Louisiana) | 439.24 mi (706.88 km) |
