| Simi Valley to Enterprise (Nevada) | 232.53 mi (374.23 km) |
| Simi Valley to Enumclaw (Washington) | 909.50 mi (1,463.70 km) |
| Simi Valley to Ephrata (Pennsylvania) | 2,354.47 mi (3,789.16 km) |
| Simi Valley to Erie (Colorado) | 852.52 mi (1,372.00 km) |
| Simi Valley to Erie (Pennsylvania) | 2,149.41 mi (3,459.14 km) |
| Simi Valley to Erlanger (Kentucky) | 1,910.70 mi (3,074.97 km) |
| Simi Valley to Escanaba (Michigan) | 1,837.75 mi (2,957.57 km) |
| Simi Valley to Escondido (California) | 124.10 mi (199.72 km) |
| Simi Valley to Española (New Mexico) | 725.94 mi (1,168.29 km) |
| Simi Valley to Essex (Maryland) | 2,345.17 mi (3,774.19 km) |
| Simi Valley to Essex Junction (Vermont) | 2,502.24 mi (4,026.97 km) |
| Simi Valley to Estelle (Louisiana) | 1,699.30 mi (2,734.76 km) |
| Simi Valley to Estero (Florida) | 2,255.83 mi (3,630.40 km) |
| Simi Valley to Euclid (Ohio) | 2,073.95 mi (3,337.70 km) |
| Simi Valley to Eufaula (Alabama) | 1,942.98 mi (3,126.93 km) |
