| Simi Valley to Orangeburg (South Carolina) | 2,160.95 mi (3,477.71 km) |
| Simi Valley to Orangevale (California) | 334.93 mi (539.01 km) |
| Simi Valley to Orchards (Washington) | 813.98 mi (1,309.97 km) |
| Simi Valley to Orcutt (California) | 103.91 mi (167.22 km) |
| Simi Valley to Oregon (Ohio) | 1,975.41 mi (3,179.12 km) |
| Simi Valley to Oregon (Wisconsin) | 1,684.04 mi (2,710.19 km) |
| Simi Valley to Oregon City (Oregon) | 791.71 mi (1,274.14 km) |
| Simi Valley to Orem (Utah) | 568.71 mi (915.25 km) |
| Simi Valley to Orinda (California) | 314.68 mi (506.43 km) |
| Simi Valley to Orland Park (Illinois) | 1,747.27 mi (2,811.95 km) |
| Simi Valley to Orlando (Florida) | 2,230.22 mi (3,589.20 km) |
| Simi Valley to Ormond Beach (Florida) | 2,224.92 mi (3,580.66 km) |
| Simi Valley to Oro Valley (Arizona) | 466.24 mi (750.34 km) |
| Simi Valley to Oroville (California) | 393.58 mi (633.40 km) |
| Simi Valley to Oshkosh (Wisconsin) | 1,740.02 mi (2,800.29 km) |
