| Simi Valley to Southern Pines (North Carolina) | 2,220.37 mi (3,573.33 km) |
| Simi Valley to Southfield (Michigan) | 1,988.15 mi (3,199.61 km) |
| Simi Valley to Southgate (Michigan) | 1,989.50 mi (3,201.79 km) |
| Simi Valley to Southlake (Texas) | 1,243.81 mi (2,001.71 km) |
| Simi Valley to Spanaway (Washington) | 906.96 mi (1,459.61 km) |
| Simi Valley to Spanish Fork (Utah) | 561.86 mi (904.23 km) |
| Simi Valley to Spanish Lake (Missouri) | 1,608.31 mi (2,588.32 km) |
| Simi Valley to Spanish Springs (Nevada) | 375.89 mi (604.94 km) |
| Simi Valley to Sparks (Nevada) | 370.56 mi (596.36 km) |
| Simi Valley to Spartanburg (South Carolina) | 2,082.72 mi (3,351.81 km) |
| Simi Valley to Spearfish (South Dakota) | 1,062.36 mi (1,709.70 km) |
| Simi Valley to Speedway (Indiana) | 1,822.39 mi (2,932.85 km) |
| Simi Valley to Spencer (Iowa) | 1,405.88 mi (2,262.55 km) |
| Simi Valley to Spokane (Washington) | 928.41 mi (1,494.13 km) |
| Simi Valley to Spokane Valley (Washington) | 928.91 mi (1,494.94 km) |
