| Sint-Joost-ten-Node to Sestao | 625.57 mi (1,006.76 km) |
| Sint-Joost-ten-Node to Sevilla | 1,069.84 mi (1,721.75 km) |
| Sint-Joost-ten-Node to Sevilla La Nueva | 830.59 mi (1,336.70 km) |
| Sint-Joost-ten-Node to Silla | 827.01 mi (1,330.94 km) |
| Sint-Joost-ten-Node to Silleda | 818.60 mi (1,317.41 km) |
| Sint-Joost-ten-Node to Sitges | 675.71 mi (1,087.45 km) |
| Sint-Joost-ten-Node to Socuellamos | 870.91 mi (1,401.60 km) |
| Sint-Joost-ten-Node to Soller | 770.08 mi (1,239.33 km) |
| Sint-Joost-ten-Node to Solsona | 626.77 mi (1,008.69 km) |
| Sint-Joost-ten-Node to Son Servera | 777.44 mi (1,251.17 km) |
| Sint-Joost-ten-Node to Sonseca | 869.15 mi (1,398.76 km) |
| Sint-Joost-ten-Node to Sopelana | 620.71 mi (998.93 km) |
| Sint-Joost-ten-Node to Soria | 706.92 mi (1,137.68 km) |
| Sint-Joost-ten-Node to Suances | 646.95 mi (1,041.16 km) |
| Sint-Joost-ten-Node to Sueca | 836.33 mi (1,345.94 km) |
