| Sint-Joost-ten-Node to Southern Pines (North Carolina) | 4,132.89 mi (6,651.25 km) |
| Sint-Joost-ten-Node to Southfield (Michigan) | 3,946.87 mi (6,351.87 km) |
| Sint-Joost-ten-Node to Southgate (Michigan) | 3,957.18 mi (6,368.46 km) |
| Sint-Joost-ten-Node to Southlake (Texas) | 4,945.93 mi (7,959.70 km) |
| Sint-Joost-ten-Node to Spanaway (Washington) | 4,968.25 mi (7,995.63 km) |
| Sint-Joost-ten-Node to Spanish Fork (Utah) | 5,062.86 mi (8,147.89 km) |
| Sint-Joost-ten-Node to Spanish Lake (Missouri) | 4,386.46 mi (7,059.32 km) |
| Sint-Joost-ten-Node to Spanish Springs (Nevada) | 5,329.18 mi (8,576.49 km) |
| Sint-Joost-ten-Node to Sparks (Nevada) | 5,335.37 mi (8,586.44 km) |
| Sint-Joost-ten-Node to Spartanburg (South Carolina) | 4,247.66 mi (6,835.95 km) |
| Sint-Joost-ten-Node to Spearfish (South Dakota) | 4,577.19 mi (7,366.27 km) |
| Sint-Joost-ten-Node to Speedway (Indiana) | 4,186.66 mi (6,737.77 km) |
| Sint-Joost-ten-Node to Spencer (Iowa) | 4,352.75 mi (7,005.07 km) |
| Sint-Joost-ten-Node to Spokane (Washington) | 4,806.54 mi (7,735.38 km) |
| Sint-Joost-ten-Node to Spokane Valley (Washington) | 4,801.50 mi (7,727.27 km) |
