| Siracusa to Sacile | 631.33 mi (1,016.03 km) |
| Siracusa to Sala Consilina | 230.75 mi (371.36 km) |
| Siracusa to Salemi | 145.90 mi (234.80 km) |
| Siracusa to Salerno | 251.13 mi (404.16 km) |
| Siracusa to Salo | 638.64 mi (1,027.79 km) |
| Siracusa to Salsomaggiore Terme | 602.28 mi (969.28 km) |
| Siracusa to Saluzzo | 662.67 mi (1,066.46 km) |
| Siracusa to Salzano | 607.39 mi (977.51 km) |
| Siracusa to Samarate | 679.60 mi (1,093.71 km) |
| Siracusa to San Benedetto del Tronto | 413.04 mi (664.73 km) |
| Siracusa to San Biagio di Callalta | 614.06 mi (988.23 km) |
| Siracusa to San Bonifacio | 611.84 mi (984.66 km) |
| Siracusa to San Casciano in Val di Pesa | 503.62 mi (810.50 km) |
| Siracusa to San Cataldo | 77.20 mi (124.24 km) |
| Siracusa to San Cesareo | 353.81 mi (569.40 km) |
