| Siracusa to Selargius | 365.37 mi (588.00 km) |
| Siracusa to Selvazzano Dentro | 602.46 mi (969.56 km) |
| Siracusa to Senago | 668.85 mi (1,076.41 km) |
| Siracusa to Senigallia | 471.74 mi (759.19 km) |
| Siracusa to Seravezza | 547.23 mi (880.69 km) |
| Siracusa to Seregno | 671.20 mi (1,080.19 km) |
| Siracusa to Seriate | 661.20 mi (1,064.10 km) |
| Siracusa to Sermoneta | 333.16 mi (536.17 km) |
| Siracusa to Serramanna | 381.67 mi (614.23 km) |
| Siracusa to Serravalle Pistoiese | 526.61 mi (847.50 km) |
| Siracusa to Sessa Aurunca | 296.71 mi (477.51 km) |
| Siracusa to Sesto Calende | 690.27 mi (1,110.89 km) |
| Siracusa to Sesto Fiorentino | 514.22 mi (827.56 km) |
| Siracusa to Sesto San Giovanni | 663.42 mi (1,067.67 km) |
| Siracusa to Sestri Levante | 585.43 mi (942.16 km) |
