| South Portland to Sacile | 3,869.10 mi (6,226.71 km) |
| South Portland to Sala Consilina | 4,206.04 mi (6,768.96 km) |
| South Portland to Salemi | 4,182.67 mi (6,731.36 km) |
| South Portland to Salerno | 4,158.62 mi (6,692.66 km) |
| South Portland to Salo | 3,799.24 mi (6,114.28 km) |
| South Portland to Salsomaggiore Terme | 3,802.35 mi (6,119.30 km) |
| South Portland to Saluzzo | 3,701.13 mi (5,956.39 km) |
| South Portland to Salzano | 3,868.07 mi (6,225.07 km) |
| South Portland to Samarate | 3,724.59 mi (5,994.14 km) |
| South Portland to San Benedetto del Tronto | 4,035.29 mi (6,494.17 km) |
| South Portland to San Biagio di Callalta | 3,873.84 mi (6,234.34 km) |
| South Portland to San Bonifacio | 3,837.65 mi (6,176.11 km) |
| South Portland to San Casciano in Val di Pesa | 3,894.13 mi (6,267.00 km) |
| South Portland to San Cataldo | 4,249.01 mi (6,838.12 km) |
| South Portland to San Cesareo | 4,030.48 mi (6,486.43 km) |
