| South Portland to Spello | 3,981.95 mi (6,408.32 km) |
| South Portland to Spilamberto | 3,856.24 mi (6,206.01 km) |
| South Portland to Spilimbergo | 3,879.50 mi (6,243.45 km) |
| South Portland to Spinea | 3,871.31 mi (6,230.27 km) |
| South Portland to Spoleto | 3,990.98 mi (6,422.86 km) |
| South Portland to Spoltore | 4,064.64 mi (6,541.41 km) |
| South Portland to Spresiano | 3,865.01 mi (6,220.13 km) |
| South Portland to Squinzano | 4,310.60 mi (6,937.24 km) |
| South Portland to Statte | 4,268.75 mi (6,869.89 km) |
| South Portland to Stezzano | 3,760.33 mi (6,051.67 km) |
| South Portland to Strada | 3,902.36 mi (6,280.24 km) |
| South Portland to Stradella | 3,764.29 mi (6,058.05 km) |
| South Portland to Striano | 4,145.00 mi (6,670.73 km) |
| South Portland to Subiaco | 4,039.18 mi (6,500.44 km) |
| South Portland to Sulmona | 4,070.64 mi (6,551.07 km) |
