| South Portland to Shoreham-by-Sea | 3,197.27 mi (5,145.50 km) |
| South Portland to Shotley Bridge | 3,050.87 mi (4,909.90 km) |
| South Portland to Shrewsbury | 3,056.18 mi (4,918.45 km) |
| South Portland to Sidcup | 3,198.89 mi (5,148.12 km) |
| South Portland to Sidmouth | 3,078.12 mi (4,953.75 km) |
| South Portland to Sileby | 3,121.68 mi (5,023.86 km) |
| South Portland to Sittingbourne | 3,226.79 mi (5,193.02 km) |
| South Portland to Skegness | 3,170.46 mi (5,102.35 km) |
| South Portland to Skelmersdale | 3,039.21 mi (4,891.13 km) |
| South Portland to Skipton | 3,061.38 mi (4,926.81 km) |
| South Portland to Sleaford | 3,143.71 mi (5,059.31 km) |
| South Portland to Slough | 3,168.96 mi (5,099.94 km) |
| South Portland to Small Heath | 3,097.25 mi (4,984.54 km) |
| South Portland to Smethwick | 3,092.03 mi (4,976.14 km) |
| South Portland to Snaresbrook | 3,191.65 mi (5,136.47 km) |
