| South Portland to Anoka (Minnesota) | 1,141.21 mi (1,836.59 km) |
| South Portland to Ansonia (Connecticut) | 212.15 mi (341.42 km) |
| South Portland to Antelope (California) | 2,635.69 mi (4,241.73 km) |
| South Portland to Anthem (Arizona) | 2,325.95 mi (3,743.25 km) |
| South Portland to Antioch (California) | 2,678.39 mi (4,310.46 km) |
| South Portland to Antioch (Illinois) | 899.63 mi (1,447.81 km) |
| South Portland to Apache Junction (Arizona) | 2,312.59 mi (3,721.75 km) |
| South Portland to Apex (North Carolina) | 711.14 mi (1,144.48 km) |
| South Portland to Apollo Beach (Florida) | 1,286.81 mi (2,070.92 km) |
| South Portland to Apopka (Florida) | 1,204.58 mi (1,938.59 km) |
| South Portland to Apple Valley (California) | 2,557.90 mi (4,116.55 km) |
| South Portland to Apple Valley (Minnesota) | 1,133.94 mi (1,824.89 km) |
| South Portland to Appleton (Wisconsin) | 899.55 mi (1,447.69 km) |
| South Portland to Arbutus (Maryland) | 449.10 mi (722.75 km) |
| South Portland to Arcadia (California) | 2,612.57 mi (4,204.52 km) |
