| South Portland to Des Plaines (Illinois) | 897.42 mi (1,444.25 km) |
| South Portland to Desert Hot Springs (California) | 2,543.89 mi (4,094.00 km) |
| South Portland to DeSoto (Texas) | 1,623.25 mi (2,612.38 km) |
| South Portland to Destin (Florida) | 1,273.46 mi (2,049.44 km) |
| South Portland to Destrehan (Louisiana) | 1,451.07 mi (2,335.28 km) |
| South Portland to Detroit (Michigan) | 652.43 mi (1,049.98 km) |
| South Portland to Diamond Bar (California) | 2,606.06 mi (4,194.04 km) |
| South Portland to Diamond Springs (California) | 2,610.68 mi (4,201.49 km) |
| South Portland to Dickinson (North Dakota) | 1,585.10 mi (2,550.97 km) |
| South Portland to Dickinson (Texas) | 1,677.40 mi (2,699.52 km) |
| South Portland to Dickson (Tennessee) | 1,042.97 mi (1,678.50 km) |
| South Portland to Difficult Run (Virginia) | 490.71 mi (789.72 km) |
| South Portland to Dinuba (California) | 2,602.85 mi (4,188.88 km) |
| South Portland to Discovery Bay (California) | 2,670.82 mi (4,298.26 km) |
| South Portland to Dix Hills (New York) | 249.96 mi (402.26 km) |
