| South Portland to Eatontown (New Jersey) | 301.08 mi (484.54 km) |
| South Portland to Eau Claire (Wisconsin) | 1,050.14 mi (1,690.03 km) |
| South Portland to Echelon (New Jersey) | 356.50 mi (573.74 km) |
| South Portland to Eden (North Carolina) | 700.79 mi (1,127.81 km) |
| South Portland to Eden Prairie (Minnesota) | 1,146.10 mi (1,844.46 km) |
| South Portland to Edgewater (Florida) | 1,172.18 mi (1,886.44 km) |
| South Portland to Edgewater (New Jersey) | 270.42 mi (435.20 km) |
| South Portland to Edgewood (Maryland) | 425.51 mi (684.79 km) |
| South Portland to Edgewood (Washington) | 2,486.33 mi (4,001.36 km) |
| South Portland to Edina (Minnesota) | 1,141.04 mi (1,836.33 km) |
| South Portland to Edinburg (Texas) | 1,963.90 mi (3,160.59 km) |
| South Portland to Edmond (Oklahoma) | 1,535.87 mi (2,471.75 km) |
| South Portland to Edmonds (Washington) | 2,480.11 mi (3,991.35 km) |
| South Portland to Edwards (Colorado) | 1,881.33 mi (3,027.71 km) |
| South Portland to Edwardsville (Illinois) | 1,074.00 mi (1,728.44 km) |
