| South Portland to Elyria (Ohio) | 621.14 mi (999.63 km) |
| South Portland to Emeryville (California) | 2,707.05 mi (4,356.57 km) |
| South Portland to Emmaus (Pennsylvania) | 342.05 mi (550.48 km) |
| South Portland to Emporia (Kansas) | 1,391.57 mi (2,239.52 km) |
| South Portland to Encinitas (California) | 2,610.88 mi (4,201.81 km) |
| South Portland to Endicott (New York) | 310.94 mi (500.41 km) |
| South Portland to Endwell (New York) | 308.42 mi (496.35 km) |
| South Portland to Englewood (Colorado) | 1,799.67 mi (2,896.29 km) |
| South Portland to Englewood (Florida) | 1,333.72 mi (2,146.42 km) |
| South Portland to Englewood (New Jersey) | 266.99 mi (429.68 km) |
| South Portland to Englewood (Ohio) | 766.86 mi (1,234.15 km) |
| South Portland to Enid (Oklahoma) | 1,533.96 mi (2,468.67 km) |
| South Portland to Ennis (Texas) | 1,623.60 mi (2,612.93 km) |
| South Portland to Ensley (Florida) | 1,297.54 mi (2,088.19 km) |
| South Portland to Enterprise (Alabama) | 1,200.35 mi (1,931.77 km) |
