| South Portland to Enterprise (Nevada) | 2,411.56 mi (3,881.03 km) |
| South Portland to Enumclaw (Washington) | 2,473.44 mi (3,980.61 km) |
| South Portland to Ephrata (Pennsylvania) | 385.32 mi (620.12 km) |
| South Portland to Erie (Colorado) | 1,792.73 mi (2,885.11 km) |
| South Portland to Erie (Pennsylvania) | 506.01 mi (814.34 km) |
| South Portland to Erlanger (Kentucky) | 806.25 mi (1,297.54 km) |
| South Portland to Escanaba (Michigan) | 836.48 mi (1,346.19 km) |
| South Portland to Escondido (California) | 2,598.47 mi (4,181.83 km) |
| South Portland to Española (New Mexico) | 1,953.89 mi (3,144.49 km) |
| South Portland to Essex (Maryland) | 436.83 mi (703.01 km) |
| South Portland to Essex Junction (Vermont) | 152.28 mi (245.07 km) |
| South Portland to Estelle (Louisiana) | 1,446.00 mi (2,327.10 km) |
| South Portland to Estero (Florida) | 1,352.12 mi (2,176.02 km) |
| South Portland to Euclid (Ohio) | 587.66 mi (945.74 km) |
| South Portland to Eufaula (Alabama) | 1,143.13 mi (1,839.70 km) |
