| South San Francisco to Phoenix (Arizona) | 644.64 mi (1,037.46 km) |
| South San Francisco to Seattle (Washington) | 688.69 mi (1,108.34 km) |
| South San Francisco to Denver (Colorado) | 955.46 mi (1,537.67 km) |
| South San Francisco to San Francisco (California) | 7.18 mi (11.56 km) |
| South San Francisco to Dallas (Texas) | 1,481.32 mi (2,383.96 km) |
| South San Francisco to Minneapolis (Minnesota) | 1,584.98 mi (2,550.78 km) |
| South San Francisco to Houston (Texas) | 1,638.86 mi (2,637.49 km) |
| South San Francisco to St. Louis (Missouri) | 1,740.65 mi (2,801.31 km) |
| South San Francisco to Chicago (Illinois) | 1,854.81 mi (2,985.02 km) |
| South San Francisco to Detroit (Michigan) | 2,087.01 mi (3,358.72 km) |
| South San Francisco to Atlanta (Georgia) | 2,134.07 mi (3,434.46 km) |
| South San Francisco to Tampa (Florida) | 2,395.30 mi (3,854.86 km) |
| South San Francisco to Washington (District of Columbia) | 2,438.35 mi (3,924.15 km) |
| South San Francisco to Baltimore (Maryland) | 2,453.44 mi (3,948.44 km) |
| South San Francisco to Philadelphia (Pennsylvania) | 2,520.31 mi (4,056.05 km) |
| South San Francisco to Brooklyn (New York) | 2,572.35 mi (4,139.80 km) |
| South San Francisco to New York (New York) | 2,573.01 mi (4,140.85 km) |
| South San Francisco to Queens (New York) | 2,578.77 mi (4,150.13 km) |
| South San Francisco to Miami (Florida) | 2,588.36 mi (4,165.56 km) |
| South San Francisco to Boston (Massachusetts) | 2,695.38 mi (4,337.79 km) |
| South San Francisco to Los Angeles (California) | 332.00 mi (534.31 km) |
| South San Francisco to Riverside (California) | 380.94 mi (613.07 km) |
| South San Francisco to Las Vegas (Nevada) | 406.96 mi (654.93 km) |
| South San Francisco to San Diego (California) | 447.47 mi (720.13 km) |
| South San Francisco to Portland (Oregon) | 544.81 mi (876.79 km) |
