| South San Francisco to Shoreham-by-Sea | 5,390.63 mi (8,675.38 km) |
| South San Francisco to Shotley Bridge | 5,144.40 mi (8,279.11 km) |
| South San Francisco to Shrewsbury | 5,223.88 mi (8,407.03 km) |
| South San Francisco to Sidcup | 5,371.92 mi (8,645.27 km) |
| South San Francisco to Sidmouth | 5,307.80 mi (8,542.08 km) |
| South San Francisco to Sileby | 5,271.26 mi (8,483.27 km) |
| South San Francisco to Sittingbourne | 5,394.99 mi (8,682.40 km) |
| South San Francisco to Skegness | 5,292.28 mi (8,517.11 km) |
| South San Francisco to Skelmersdale | 5,182.34 mi (8,340.17 km) |
| South San Francisco to Skipton | 5,184.28 mi (8,343.30 km) |
| South San Francisco to Sleaford | 5,278.11 mi (8,494.30 km) |
| South San Francisco to Slough | 5,347.40 mi (8,605.81 km) |
| South San Francisco to Small Heath | 5,262.55 mi (8,469.25 km) |
| South San Francisco to Smethwick | 5,257.68 mi (8,461.42 km) |
| South San Francisco to Snaresbrook | 5,361.24 mi (8,628.08 km) |
