| South San Francisco to Des Plaines (Illinois) | 1,843.23 mi (2,966.40 km) |
| South San Francisco to Desert Hot Springs (California) | 416.68 mi (670.59 km) |
| South San Francisco to DeSoto (Texas) | 1,480.78 mi (2,383.09 km) |
| South San Francisco to Destin (Florida) | 2,105.10 mi (3,387.84 km) |
| South San Francisco to Destrehan (Louisiana) | 1,904.88 mi (3,065.60 km) |
| South San Francisco to Detroit (Michigan) | 2,087.01 mi (3,358.72 km) |
| South San Francisco to Diamond Bar (California) | 360.83 mi (580.70 km) |
| South San Francisco to Diamond Springs (California) | 111.87 mi (180.04 km) |
| South San Francisco to Dickinson (North Dakota) | 1,184.16 mi (1,905.72 km) |
| South San Francisco to Dickinson (Texas) | 1,666.85 mi (2,682.54 km) |
| South San Francisco to Dickson (Tennessee) | 1,929.67 mi (3,105.51 km) |
| South San Francisco to Difficult Run (Virginia) | 2,421.04 mi (3,896.29 km) |
| South San Francisco to Dinuba (California) | 183.24 mi (294.89 km) |
| South San Francisco to Discovery Bay (California) | 48.09 mi (77.39 km) |
| South San Francisco to Dix Hills (New York) | 2,601.61 mi (4,186.89 km) |
