| South San Francisco to Effingham (Illinois) | 1,826.41 mi (2,939.32 km) |
| South San Francisco to Eggertsville (New York) | 2,300.76 mi (3,702.71 km) |
| South San Francisco to Egypt Lake-Leto (Florida) | 2,391.22 mi (3,848.30 km) |
| South San Francisco to El Cajon (California) | 455.15 mi (732.49 km) |
| South San Francisco to El Campo (Texas) | 1,610.24 mi (2,591.43 km) |
| South San Francisco to El Centro (California) | 512.59 mi (824.94 km) |
| South San Francisco to El Cerrito (California) | 19.45 mi (31.30 km) |
| South San Francisco to El Dorado (Arkansas) | 1,695.51 mi (2,728.66 km) |
| South San Francisco to El Dorado (Kansas) | 1,392.18 mi (2,240.50 km) |
| South San Francisco to El Dorado Hills (California) | 102.58 mi (165.08 km) |
| South San Francisco to El Mirage (Arizona) | 632.06 mi (1,017.20 km) |
| South San Francisco to El Monte (California) | 348.65 mi (561.10 km) |
| South San Francisco to El Paso (Texas) | 990.67 mi (1,594.33 km) |
| South San Francisco to El Paso de Robles (California) | 170.08 mi (273.72 km) |
| South San Francisco to El Reno (Oklahoma) | 1,360.39 mi (2,189.34 km) |
