| South San Francisco to Elyria (Ohio) | 2,144.70 mi (3,451.56 km) |
| South San Francisco to Emeryville (California) | 14.49 mi (23.32 km) |
| South San Francisco to Emmaus (Pennsylvania) | 2,494.26 mi (4,014.12 km) |
| South San Francisco to Emporia (Kansas) | 1,423.50 mi (2,290.91 km) |
| South San Francisco to Encinitas (California) | 430.81 mi (693.32 km) |
| South San Francisco to Endicott (New York) | 2,446.86 mi (3,937.84 km) |
| South San Francisco to Endwell (New York) | 2,448.77 mi (3,940.92 km) |
| South San Francisco to Englewood (Colorado) | 948.76 mi (1,526.88 km) |
| South San Francisco to Englewood (Florida) | 2,432.67 mi (3,915.01 km) |
| South San Francisco to Englewood (New Jersey) | 2,567.81 mi (4,132.50 km) |
| South San Francisco to Englewood (Ohio) | 2,043.56 mi (3,288.79 km) |
| South San Francisco to Enid (Oklahoma) | 1,353.00 mi (2,177.44 km) |
| South San Francisco to Ennis (Texas) | 1,500.03 mi (2,414.06 km) |
| South San Francisco to Ensley (Florida) | 2,057.63 mi (3,311.43 km) |
| South San Francisco to Enterprise (Alabama) | 2,114.23 mi (3,402.52 km) |
