| South San Francisco to Enterprise (Nevada) | 413.51 mi (665.49 km) |
| South San Francisco to Enumclaw (Washington) | 660.06 mi (1,062.27 km) |
| South San Francisco to Ephrata (Pennsylvania) | 2,463.68 mi (3,964.91 km) |
| South San Francisco to Erie (Colorado) | 948.06 mi (1,525.75 km) |
| South San Francisco to Erie (Pennsylvania) | 2,242.97 mi (3,609.71 km) |
| South San Francisco to Erlanger (Kentucky) | 2,037.84 mi (3,279.58 km) |
| South San Francisco to Escanaba (Michigan) | 1,889.03 mi (3,040.10 km) |
| South San Francisco to Escondido (California) | 433.66 mi (697.90 km) |
| South San Francisco to Española (New Mexico) | 910.25 mi (1,464.90 km) |
| South San Francisco to Essex (Maryland) | 2,462.34 mi (3,962.76 km) |
| South San Francisco to Essex Junction (Vermont) | 2,571.39 mi (4,138.26 km) |
| South San Francisco to Estelle (Louisiana) | 1,922.73 mi (3,094.33 km) |
| South San Francisco to Estero (Florida) | 2,480.75 mi (3,992.38 km) |
| South San Francisco to Euclid (Ohio) | 2,173.19 mi (3,497.42 km) |
| South San Francisco to Eufaula (Alabama) | 2,137.46 mi (3,439.91 km) |
