| South San Francisco to Indianapolis (Indiana) | 1,947.69 mi (3,134.50 km) |
| South San Francisco to Indianola (Iowa) | 1,551.98 mi (2,497.66 km) |
| South San Francisco to Indio (California) | 440.02 mi (708.15 km) |
| South San Francisco to Inglewood (California) | 342.56 mi (551.30 km) |
| South San Francisco to Inkster (Michigan) | 2,076.67 mi (3,342.07 km) |
| South San Francisco to Inver Grove Heights (Minnesota) | 1,593.73 mi (2,564.85 km) |
| South San Francisco to Inwood (New York) | 2,582.96 mi (4,156.88 km) |
| South San Francisco to Iona (Florida) | 2,468.87 mi (3,973.26 km) |
| South San Francisco to Ionia (Michigan) | 1,984.76 mi (3,194.17 km) |
| South San Francisco to Iowa City (Iowa) | 1,657.13 mi (2,666.90 km) |
| South San Francisco to Irmo (South Carolina) | 2,302.39 mi (3,705.34 km) |
| South San Francisco to Irondale (Alabama) | 2,016.63 mi (3,245.46 km) |
| South San Francisco to Ironton (Ohio) | 2,144.89 mi (3,451.86 km) |
| South San Francisco to Irvine (California) | 378.71 mi (609.47 km) |
| South San Francisco to Irving (Texas) | 1,468.69 mi (2,363.63 km) |
