| South San Francisco to Isabela (Puerto Rico) | 3,570.02 mi (5,745.39 km) |
| South San Francisco to Iselin (New Jersey) | 2,554.57 mi (4,111.19 km) |
| South San Francisco to Isla Vista (California) | 265.63 mi (427.50 km) |
| South San Francisco to Issaquah (Washington) | 683.60 mi (1,100.15 km) |
| South San Francisco to Ithaca (New York) | 2,421.19 mi (3,896.53 km) |
| South San Francisco to Ives Estates (Florida) | 2,583.85 mi (4,158.30 km) |
| South San Francisco to Jackson (Michigan) | 2,021.38 mi (3,253.10 km) |
| South San Francisco to Jackson (Mississippi) | 1,850.63 mi (2,978.30 km) |
| South San Francisco to Jackson (Missouri) | 1,786.61 mi (2,875.26 km) |
| South San Francisco to Jackson (Tennessee) | 1,856.79 mi (2,988.22 km) |
| South San Francisco to Jackson (Wyoming) | 730.51 mi (1,175.65 km) |
| South San Francisco to Jacksonville (Alabama) | 2,060.38 mi (3,315.87 km) |
| South San Francisco to Jacksonville (Arkansas) | 1,690.80 mi (2,721.09 km) |
| South San Francisco to Jacksonville (Florida) | 2,369.03 mi (3,812.58 km) |
| South San Francisco to Jacksonville (Illinois) | 1,732.44 mi (2,788.10 km) |
