| South San Francisco to LaGrange (Georgia) | 2,116.84 mi (3,406.72 km) |
| South San Francisco to Laguna Beach (California) | 385.97 mi (621.16 km) |
| South San Francisco to Laguna Hills (California) | 385.97 mi (621.15 km) |
| South San Francisco to Laguna Niguel (California) | 389.05 mi (626.12 km) |
| South San Francisco to Laguna Woods (California) | 383.85 mi (617.75 km) |
| South San Francisco to Lahaina (Hawaii) | 2,347.59 mi (3,778.08 km) |
| South San Francisco to Lake Arbor (Maryland) | 2,448.02 mi (3,939.71 km) |
| South San Francisco to Lake Barcroft (Virginia) | 2,431.73 mi (3,913.49 km) |
| South San Francisco to Lake Butler (Florida) | 2,429.35 mi (3,909.65 km) |
| South San Francisco to Lake Charles (Louisiana) | 1,743.73 mi (2,806.27 km) |
| South San Francisco to Lake City (Florida) | 2,319.78 mi (3,733.32 km) |
| South San Francisco to Lake Elmo (Minnesota) | 1,602.93 mi (2,579.66 km) |
| South San Francisco to Lake Elsinore (California) | 395.70 mi (636.82 km) |
| South San Francisco to Lake Forest (California) | 383.53 mi (617.23 km) |
| South San Francisco to Lake Forest (Illinois) | 1,844.86 mi (2,969.01 km) |
