| South San Francisco to Los Alamitos (California) | 361.61 mi (581.95 km) |
| South San Francisco to Los Alamos (New Mexico) | 900.00 mi (1,448.41 km) |
| South San Francisco to Los Altos (California) | 26.50 mi (42.65 km) |
| South San Francisco to Los Angeles (California) | 332.00 mi (534.31 km) |
| South San Francisco to Los Banos (California) | 95.84 mi (154.24 km) |
| South San Francisco to Los Gatos (California) | 38.76 mi (62.37 km) |
| South San Francisco to Los Lunas (New Mexico) | 892.31 mi (1,436.03 km) |
| South San Francisco to Los Osos (California) | 184.81 mi (297.43 km) |
| South San Francisco to Loudoun Valley Estates (Virginia) | 2,411.62 mi (3,881.12 km) |
| South San Francisco to Louisville (Colorado) | 942.20 mi (1,516.32 km) |
| South San Francisco to Louisville (Kentucky) | 1,991.50 mi (3,205.01 km) |
| South San Francisco to Lovejoy (Georgia) | 2,146.80 mi (3,454.95 km) |
| South San Francisco to Loveland (Colorado) | 949.25 mi (1,527.67 km) |
| South San Francisco to Loveland (Ohio) | 2,051.52 mi (3,301.60 km) |
| South San Francisco to Loves Park (Illinois) | 1,786.55 mi (2,875.18 km) |
