| South San Francisco to Lovington (New Mexico) | 1,123.20 mi (1,807.61 km) |
| South San Francisco to Lowell (Indiana) | 1,870.76 mi (3,010.70 km) |
| South San Francisco to Lowell (Massachusetts) | 2,679.46 mi (4,312.17 km) |
| South San Francisco to Lower Burrell (Pennsylvania) | 2,275.78 mi (3,662.51 km) |
| South San Francisco to Lowes Island (Virginia) | 2,418.60 mi (3,892.37 km) |
| South San Francisco to Lubbock (Texas) | 1,184.76 mi (1,906.68 km) |
| South San Francisco to Lufkin (Texas) | 1,629.92 mi (2,623.10 km) |
| South San Francisco to Luling (Louisiana) | 1,907.50 mi (3,069.83 km) |
| South San Francisco to Lumberton (North Carolina) | 2,409.09 mi (3,877.06 km) |
| South San Francisco to Lumberton (Texas) | 1,688.28 mi (2,717.03 km) |
| South San Francisco to Lutz (Florida) | 2,390.71 mi (3,847.48 km) |
| South San Francisco to Lynbrook (New York) | 2,586.38 mi (4,162.38 km) |
| South San Francisco to Lynchburg (Virginia) | 2,347.25 mi (3,777.53 km) |
| South San Francisco to Lynden (Washington) | 780.51 mi (1,256.11 km) |
| South San Francisco to Lyndhurst (Ohio) | 2,175.14 mi (3,500.56 km) |
