| South San Francisco to Odenton (Maryland) | 2,452.83 mi (3,947.45 km) |
| South San Francisco to Odessa (Texas) | 1,204.31 mi (1,938.16 km) |
| South San Francisco to Ogden (Utah) | 609.37 mi (980.69 km) |
| South San Francisco to Oildale (California) | 242.90 mi (390.91 km) |
| South San Francisco to Ojus (Florida) | 2,585.30 mi (4,160.63 km) |
| South San Francisco to Okemos (Michigan) | 2,018.97 mi (3,249.22 km) |
| South San Francisco to Oklahoma City (Oklahoma) | 1,386.35 mi (2,231.11 km) |
| South San Francisco to Okmulgee (Oklahoma) | 1,466.37 mi (2,359.90 km) |
| South San Francisco to Olathe (Kansas) | 1,493.88 mi (2,404.17 km) |
| South San Francisco to Old Jamestown (Missouri) | 1,736.65 mi (2,794.87 km) |
| South San Francisco to Oldsmar (Florida) | 2,381.28 mi (3,832.31 km) |
| South San Francisco to Olean (New York) | 2,326.78 mi (3,744.59 km) |
| South San Francisco to Olive Branch (Mississippi) | 1,814.01 mi (2,919.36 km) |
| South San Francisco to Olivehurst (California) | 109.04 mi (175.48 km) |
| South San Francisco to Olney (Maryland) | 2,431.86 mi (3,913.70 km) |
