| South San Francisco to Orangeburg (South Carolina) | 2,333.75 mi (3,755.81 km) |
| South San Francisco to Orangevale (California) | 96.68 mi (155.58 km) |
| South San Francisco to Orchards (Washington) | 555.21 mi (893.52 km) |
| South San Francisco to Orcutt (California) | 222.25 mi (357.68 km) |
| South San Francisco to Oregon (Ohio) | 2,074.47 mi (3,338.53 km) |
| South San Francisco to Oregon (Wisconsin) | 1,766.56 mi (2,843.00 km) |
| South San Francisco to Oregon City (Oregon) | 531.26 mi (854.99 km) |
| South San Francisco to Orem (Utah) | 603.65 mi (971.48 km) |
| South San Francisco to Orinda (California) | 20.46 mi (32.93 km) |
| South San Francisco to Orland Park (Illinois) | 1,846.57 mi (2,971.77 km) |
| South San Francisco to Orlando (Florida) | 2,441.03 mi (3,928.46 km) |
| South San Francisco to Ormond Beach (Florida) | 2,429.62 mi (3,910.09 km) |
| South San Francisco to Oro Valley (Arizona) | 740.68 mi (1,192.01 km) |
| South San Francisco to Oroville (California) | 135.68 mi (218.35 km) |
| South San Francisco to Oshkosh (Wisconsin) | 1,809.97 mi (2,912.86 km) |
