| South San Francisco to Sacramento (California) | 81.61 mi (131.34 km) |
| South San Francisco to Saddlebrooke (Arizona) | 740.75 mi (1,192.12 km) |
| South San Francisco to Safety Harbor (Florida) | 2,381.15 mi (3,832.09 km) |
| South San Francisco to Saginaw (Michigan) | 2,040.15 mi (3,283.31 km) |
| South San Francisco to Saginaw (Texas) | 1,446.99 mi (2,328.71 km) |
| South San Francisco to Sahuarita (Arizona) | 759.84 mi (1,222.84 km) |
| South San Francisco to Saks (Alabama) | 2,057.06 mi (3,310.52 km) |
| South San Francisco to Salem (Massachusetts) | 2,702.04 mi (4,348.51 km) |
| South San Francisco to Salem (Ohio) | 2,213.71 mi (3,562.61 km) |
| South San Francisco to Salem (Oregon) | 503.25 mi (809.90 km) |
| South San Francisco to Salem (Virginia) | 2,303.04 mi (3,706.38 km) |
| South San Francisco to Salem Lakes (Wisconsin) | 1,830.53 mi (2,945.95 km) |
| South San Francisco to Salida (California) | 73.12 mi (117.67 km) |
| South San Francisco to Salina (Kansas) | 1,344.49 mi (2,163.76 km) |
| South San Francisco to Salinas (California) | 79.57 mi (128.06 km) |
