| South San Francisco to Sanford (Florida) | 2,435.05 mi (3,918.83 km) |
| South San Francisco to Sanford (Maine) | 2,698.08 mi (4,342.14 km) |
| South San Francisco to Sanford (North Carolina) | 2,382.94 mi (3,834.98 km) |
| South San Francisco to Sanger (California) | 170.81 mi (274.89 km) |
| South San Francisco to Santa Ana (California) | 371.49 mi (597.86 km) |
| South San Francisco to Santa Barbara (California) | 269.05 mi (432.99 km) |
| South San Francisco to Santa Clara (California) | 31.81 mi (51.19 km) |
| South San Francisco to Santa Clara (Oregon) | 448.01 mi (721.00 km) |
| South San Francisco to Santa Clarita (California) | 313.06 mi (503.83 km) |
| South San Francisco to Santa Cruz (California) | 51.21 mi (82.41 km) |
| South San Francisco to Santa Fe (New Mexico) | 920.21 mi (1,480.94 km) |
| South San Francisco to Santa Fe (Texas) | 1,666.72 mi (2,682.32 km) |
| South San Francisco to Santa Fe Springs (California) | 354.48 mi (570.49 km) |
| South San Francisco to Santa Maria (California) | 217.81 mi (350.53 km) |
| South San Francisco to Santa Monica (California) | 333.97 mi (537.47 km) |
