| South San Francisco to Santa Paula (California) | 295.10 mi (474.91 km) |
| South San Francisco to Santa Rosa (California) | 56.91 mi (91.58 km) |
| South San Francisco to Santaquin (Utah) | 593.61 mi (955.32 km) |
| South San Francisco to Santee (California) | 451.41 mi (726.48 km) |
| South San Francisco to Sapulpa (Oklahoma) | 1,455.17 mi (2,341.88 km) |
| South San Francisco to Saraland (Alabama) | 2,003.69 mi (3,224.63 km) |
| South San Francisco to Sarasota (Florida) | 2,410.51 mi (3,879.34 km) |
| South San Francisco to Sarasota Springs (Florida) | 2,415.20 mi (3,886.90 km) |
| South San Francisco to Saratoga (California) | 34.27 mi (55.15 km) |
| South San Francisco to Saratoga Springs (New York) | 2,551.90 mi (4,106.88 km) |
| South San Francisco to Saratoga Springs (Utah) | 593.45 mi (955.06 km) |
| South San Francisco to Sartell (Minnesota) | 1,546.82 mi (2,489.37 km) |
| South San Francisco to Satellite Beach (Florida) | 2,490.28 mi (4,007.71 km) |
| South San Francisco to Sauk Rapids (Minnesota) | 1,549.73 mi (2,494.05 km) |
| South San Francisco to Sault Ste. Marie (Michigan) | 2,022.51 mi (3,254.91 km) |
