| South San Francisco to Secaucus (New Jersey) | 2,564.58 mi (4,127.30 km) |
| South San Francisco to Security-Widefield (Colorado) | 962.81 mi (1,549.49 km) |
| South San Francisco to Sedalia (Missouri) | 1,580.11 mi (2,542.93 km) |
| South San Francisco to Sedro-Woolley (Washington) | 750.23 mi (1,207.38 km) |
| South San Francisco to Seguin (Texas) | 1,507.57 mi (2,426.20 km) |
| South San Francisco to Selden (New York) | 2,615.55 mi (4,209.32 km) |
| South San Francisco to Selma (Alabama) | 2,022.07 mi (3,254.21 km) |
| South San Francisco to Selma (California) | 171.70 mi (276.32 km) |
| South San Francisco to Selma (Texas) | 1,489.36 mi (2,396.89 km) |
| South San Francisco to Seminole (Florida) | 2,381.48 mi (3,832.62 km) |
| South San Francisco to Seven Hills (Ohio) | 2,166.93 mi (3,487.33 km) |
| South San Francisco to Seven Oaks (South Carolina) | 2,306.40 mi (3,711.79 km) |
| South San Francisco to Severn (Maryland) | 2,451.70 mi (3,945.63 km) |
| South San Francisco to Severna Park (Maryland) | 2,459.07 mi (3,957.49 km) |
| South San Francisco to Sevierville (Tennessee) | 2,138.39 mi (3,441.41 km) |
