| South San Francisco to Seymour (Indiana) | 1,969.38 mi (3,169.41 km) |
| South San Francisco to Seymour (Tennessee) | 2,127.79 mi (3,424.34 km) |
| South San Francisco to Shady Hills (Florida) | 2,377.17 mi (3,825.68 km) |
| South San Francisco to Shafter (California) | 233.35 mi (375.55 km) |
| South San Francisco to Shaker Heights (Ohio) | 2,172.54 mi (3,496.36 km) |
| South San Francisco to Shakopee (Minnesota) | 1,572.97 mi (2,531.45 km) |
| South San Francisco to Sharon (Pennsylvania) | 2,228.64 mi (3,586.65 km) |
| South San Francisco to Sharonville (Ohio) | 2,044.29 mi (3,289.97 km) |
| South San Francisco to Shasta Lake (California) | 209.03 mi (336.41 km) |
| South San Francisco to Shawnee (Kansas) | 1,493.70 mi (2,403.88 km) |
| South San Francisco to Shawnee (Oklahoma) | 1,418.25 mi (2,282.46 km) |
| South San Francisco to Sheboygan (Wisconsin) | 1,850.72 mi (2,978.45 km) |
| South San Francisco to Shelby (North Carolina) | 2,258.96 mi (3,635.45 km) |
| South San Francisco to Shelbyville (Indiana) | 1,969.26 mi (3,169.21 km) |
| South San Francisco to Shelbyville (Kentucky) | 2,013.37 mi (3,240.20 km) |
