| South San Francisco to Smithville (Missouri) | 1,503.99 mi (2,420.44 km) |
| South San Francisco to Smyrna (Delaware) | 2,506.15 mi (4,033.25 km) |
| South San Francisco to Smyrna (Georgia) | 2,126.74 mi (3,422.65 km) |
| South San Francisco to Smyrna (Tennessee) | 1,976.81 mi (3,181.37 km) |
| South San Francisco to Snellville (Georgia) | 2,154.86 mi (3,467.91 km) |
| South San Francisco to Snoqualmie (Washington) | 682.96 mi (1,099.12 km) |
| South San Francisco to Snyder (Texas) | 1,258.42 mi (2,025.24 km) |
| South San Francisco to Socastee (South Carolina) | 2,430.38 mi (3,911.32 km) |
| South San Francisco to Socorro (Texas) | 1,006.35 mi (1,619.57 km) |
| South San Francisco to Soddy-Daisy (Tennessee) | 2,062.91 mi (3,319.93 km) |
| South San Francisco to Solana Beach (California) | 433.81 mi (698.16 km) |
| South San Francisco to Soledad (California) | 102.58 mi (165.09 km) |
| South San Francisco to Solon (Ohio) | 2,178.90 mi (3,506.60 km) |
| South San Francisco to Somers Point (New Jersey) | 2,558.00 mi (4,116.71 km) |
| South San Francisco to Somerset (Kentucky) | 2,062.26 mi (3,318.88 km) |
