| South San Francisco to Somerset (New Jersey) | 2,545.96 mi (4,097.33 km) |
| South San Francisco to Somersworth (New Hampshire) | 2,693.73 mi (4,335.14 km) |
| South San Francisco to Somerton (Arizona) | 558.41 mi (898.67 km) |
| South San Francisco to Somerville (Massachusetts) | 2,693.63 mi (4,334.98 km) |
| South San Francisco to Somerville (New Jersey) | 2,539.55 mi (4,087.02 km) |
| South San Francisco to Sonoma (California) | 44.03 mi (70.85 km) |
| South San Francisco to Soquel (California) | 52.20 mi (84.01 km) |
| South San Francisco to South Bend (Indiana) | 1,928.35 mi (3,103.39 km) |
| South San Francisco to South Bradenton (Florida) | 2,404.50 mi (3,869.66 km) |
| South San Francisco to South Burlington (Vermont) | 2,566.44 mi (4,130.28 km) |
| South San Francisco to South Charleston (West Virginia) | 2,198.53 mi (3,538.19 km) |
| South San Francisco to South Daytona (Florida) | 2,438.73 mi (3,924.75 km) |
| South San Francisco to South El Monte (California) | 349.13 mi (561.87 km) |
| South San Francisco to South Elgin (Illinois) | 1,822.17 mi (2,932.50 km) |
| South San Francisco to South Euclid (Ohio) | 2,173.43 mi (3,497.80 km) |
