| South San Francisco to Southern Pines (North Carolina) | 2,376.62 mi (3,824.79 km) |
| South San Francisco to Southfield (Michigan) | 2,078.49 mi (3,345.01 km) |
| South San Francisco to Southgate (Michigan) | 2,082.71 mi (3,351.80 km) |
| South San Francisco to Southlake (Texas) | 1,456.59 mi (2,344.16 km) |
| South San Francisco to Spanaway (Washington) | 652.52 mi (1,050.14 km) |
| South San Francisco to Spanish Fork (Utah) | 603.63 mi (971.46 km) |
| South San Francisco to Spanish Lake (Missouri) | 1,741.23 mi (2,802.23 km) |
| South San Francisco to Spanish Springs (Nevada) | 202.89 mi (326.52 km) |
| South San Francisco to Sparks (Nevada) | 197.21 mi (317.37 km) |
| South San Francisco to Spartanburg (South Carolina) | 2,245.24 mi (3,613.36 km) |
| South San Francisco to Spearfish (South Dakota) | 1,074.70 mi (1,729.57 km) |
| South San Francisco to Speedway (Indiana) | 1,942.15 mi (3,125.59 km) |
| South San Francisco to Spencer (Iowa) | 1,476.76 mi (2,376.62 km) |
| South San Francisco to Spokane (Washington) | 736.38 mi (1,185.09 km) |
| South San Francisco to Spokane Valley (Washington) | 739.59 mi (1,190.25 km) |
