| South San Francisco to Spout Springs (North Carolina) | 2,395.01 mi (3,854.40 km) |
| South San Francisco to Spring (Texas) | 1,630.74 mi (2,624.42 km) |
| South San Francisco to Spring Creek (Nevada) | 422.91 mi (680.62 km) |
| South San Francisco to Spring Hill (Florida) | 2,375.79 mi (3,823.47 km) |
| South San Francisco to Spring Hill (Tennessee) | 1,959.78 mi (3,153.96 km) |
| South San Francisco to Spring Lake (North Carolina) | 2,398.79 mi (3,860.48 km) |
| South San Francisco to Spring Valley (California) | 458.20 mi (737.40 km) |
| South San Francisco to Spring Valley (Nevada) | 409.80 mi (659.51 km) |
| South San Francisco to Spring Valley (New York) | 2,561.00 mi (4,121.54 km) |
| South San Francisco to Springboro (Ohio) | 2,050.40 mi (3,299.81 km) |
| South San Francisco to Springdale (Arkansas) | 1,558.49 mi (2,508.15 km) |
| South San Francisco to Springdale (New Jersey) | 2,530.56 mi (4,072.54 km) |
| South San Francisco to Springdale (Ohio) | 2,040.56 mi (3,283.97 km) |
| South San Francisco to Springfield (Illinois) | 1,762.69 mi (2,836.78 km) |
| South San Francisco to Springfield (Massachusetts) | 2,624.83 mi (4,224.25 km) |
