| South San Francisco to St. Simons (Georgia) | 2,362.12 mi (3,801.47 km) |
| South San Francisco to Stafford (Texas) | 1,634.32 mi (2,630.19 km) |
| South San Francisco to Stallings (North Carolina) | 2,310.45 mi (3,718.30 km) |
| South San Francisco to Stamford (Connecticut) | 2,586.19 mi (4,162.07 km) |
| South San Francisco to Stanford (California) | 20.99 mi (33.77 km) |
| South San Francisco to Stanton (California) | 363.94 mi (585.71 km) |
| South San Francisco to Star (Idaho) | 520.42 mi (837.53 km) |
| South San Francisco to Starkville (Mississippi) | 1,899.88 mi (3,057.56 km) |
| South San Francisco to State College (Pennsylvania) | 2,369.47 mi (3,813.29 km) |
| South San Francisco to Staten Island (New York) | 2,563.00 mi (4,124.75 km) |
| South San Francisco to Statesboro (Georgia) | 2,309.01 mi (3,715.99 km) |
| South San Francisco to Statesville (North Carolina) | 2,285.87 mi (3,678.75 km) |
| South San Francisco to Staunton (Virginia) | 2,341.94 mi (3,769.00 km) |
| South San Francisco to Steamboat Springs (Colorado) | 857.82 mi (1,380.53 km) |
| South San Francisco to Steiner Ranch (Texas) | 1,486.81 mi (2,392.78 km) |
