| South San Francisco to Storm Lake (Iowa) | 1,471.59 mi (2,368.30 km) |
| South San Francisco to Storrs (Connecticut) | 2,643.30 mi (4,253.98 km) |
| South San Francisco to Stoughton (Wisconsin) | 1,774.99 mi (2,856.57 km) |
| South San Francisco to Stow (Ohio) | 2,180.98 mi (3,509.95 km) |
| South San Francisco to Streamwood (Illinois) | 1,829.05 mi (2,943.58 km) |
| South San Francisco to Streator (Illinois) | 1,798.35 mi (2,894.17 km) |
| South San Francisco to Streetsboro (Ohio) | 2,185.01 mi (3,516.44 km) |
| South San Francisco to Strongsville (Ohio) | 2,159.36 mi (3,475.16 km) |
| South San Francisco to Stuart (Florida) | 2,540.39 mi (4,088.37 km) |
| South San Francisco to Stuarts Draft (Virginia) | 2,345.49 mi (3,774.71 km) |
| South San Francisco to Sturgis (Michigan) | 1,971.55 mi (3,172.91 km) |
| South San Francisco to Suamico (Wisconsin) | 1,836.34 mi (2,955.31 km) |
| South San Francisco to Sudley (Virginia) | 2,414.92 mi (3,886.44 km) |
| South San Francisco to Suffern (New York) | 2,556.24 mi (4,113.86 km) |
| South San Francisco to Suffolk (Virginia) | 2,495.71 mi (4,016.45 km) |
