| South San Francisco to Superior (Colorado) | 941.23 mi (1,514.77 km) |
| South San Francisco to Superior (Wisconsin) | 1,661.41 mi (2,673.79 km) |
| South San Francisco to Surprise (Arizona) | 622.75 mi (1,002.22 km) |
| South San Francisco to Susanville (California) | 214.33 mi (344.93 km) |
| South San Francisco to Sussex (Wisconsin) | 1,825.59 mi (2,938.00 km) |
| South San Francisco to Suwanee (Georgia) | 2,147.16 mi (3,455.52 km) |
| South San Francisco to Swansea (Illinois) | 1,755.35 mi (2,824.96 km) |
| South San Francisco to Sweetwater (Florida) | 2,579.52 mi (4,151.33 km) |
| South San Francisco to Sweetwater (Texas) | 1,291.86 mi (2,079.05 km) |
| South San Francisco to Sycamore (Illinois) | 1,803.24 mi (2,902.03 km) |
| South San Francisco to Sylacauga (Alabama) | 2,046.62 mi (3,293.72 km) |
| South San Francisco to Sylvania (Ohio) | 2,059.86 mi (3,315.02 km) |
| South San Francisco to Syosset (New York) | 2,593.01 mi (4,173.05 km) |
| South San Francisco to Syracuse (New York) | 2,433.83 mi (3,916.86 km) |
| South San Francisco to Syracuse (Utah) | 601.03 mi (967.26 km) |
